Account PROTAC KRAS G12C degrader-2
- Catalog No. :
- ACOMUV049
- CAS No. :
- 2378257-72-6
- Molecular Formula :
- C51H53ClFN9O7
- Molecular Weight :
- 958.49
IUPAC Name:5-(4-((4-((2R)-2-((4-(4-acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)oxy)propyl)piperazin-1-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
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Product Information
| Product Name | PROTAC KRAS G12C degrader-2 |
|---|---|
| IUPAC Name | 5-(4-((4-((2R)-2-((4-(4-acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)oxy)propyl)piperazin-1-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione |
| Molecular Formula | C51H53ClFN9O7 |
| Molecular Weight | 958.49 |
| SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(N4CCC(CN5CCN(C[C@H](OC6=NC(N7CCN(C(C=C)=O)CC7)=C8C=C(Cl)C(C9=C%10C=CC=CC%10=CC(O)=C9)=C(F)C8=N6)C)CC5)CC4)=C3)=O |
| InChI Key | KZQITCSEFGTWRQ-OWAVIYFHSA-N |
| Synonym | PROTAC KRAS G12C degrader-2;1H-Isoindole-1,3(2H)-dione, 5-[4-[[4-[(2R)-2-[[6-chloro-8-fluoro-7-(3-hydroxy-1-naphthalenyl)-4-[4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-2-quinazolinyl]oxy]propyl]-1-piperazinyl]methyl]-1-piperidinyl]-2-(2,6-dioxo-3-piperidinyl)- |
| CAS No. | 2378257-72-6 |
Synthetic Route by SureRoute
2. ACOMUV049 Molecular Building Block Synthetic Route
4-((12-((4-(4-Acryloylpiperazin-1-yl)-6-chloro-8-fluoro-7-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)amino)dodecyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
3-(5-(4-((4-((1-(2-((4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-7-(8-ethynyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoropyrido[4,3-d]pyrimidin-2-yl)oxy)ethyl)piperidin-4-yl)methyl)piperidin-1-yl)methyl)piperidin-1-yl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
(S)-3-(5-(2-((1-((1-(((7-(8-ethyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoro-4-((R)-3-hydroxy-3-methylpiperidin-1-yl)pyrido[4,3-d]pyrimidin-2-yl)oxy)methyl)cyclopropyl)methyl)-4-methylpiperidin-4-yl)methyl)-2,7-diazaspiro[3.5]nonan-7-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione