Account PROTAC EGFR degrader 5
- Catalog No. :
- ACOPYO559
- CAS No. :
- 2409793-36-6
- Molecular Formula :
- C57H72FN13O5S
- Molecular Weight :
- 1070.35
IUPAC Name:(2S,4R)-1-((S)-2-(7-(4-(6-((2-((4-fluorophenyl)amino)-4-(4-(hydroxymethyl)piperidin-1-yl)pyrido[3,4-d]pyrimidin-6-yl)amino)pyridin-3-yl)piperazin-1-yl)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
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Product Information
| Product Name | PROTAC EGFR degrader 5 |
|---|---|
| IUPAC Name | (2S,4R)-1-((S)-2-(7-(4-(6-((2-((4-fluorophenyl)amino)-4-(4-(hydroxymethyl)piperidin-1-yl)pyrido[3,4-d]pyrimidin-6-yl)amino)pyridin-3-yl)piperazin-1-yl)heptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Molecular Formula | C57H72FN13O5S |
| Molecular Weight | 1070.35 |
| SMILES | O=C([C@H]1N(C([C@@H](NC(CCCCCCN2CCN(C3=CC=C(NC4=CC5=C(N6CCC(CO)CC6)N=C(NC7=CC=C(F)C=C7)N=C5C=N4)N=C3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC8=CC=C(C9=C(C)N=CS9)C=C8 |
| InChI Key | LCTCXOPSLJEXKE-FEDPBZRBSA-N |
| Synonym | L-Prolinamide, N-[7-[4-[6-[[2-[(4-fluorophenyl)amino]-4-[4-(hydroxymethyl)-1-piperidinyl]pyrido[3,4-d]pyrimidin-6-yl]amino]-3-pyridinyl]-1-piperazinyl]-1-oxoheptyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- |
| CAS No. | 2409793-36-6 |
Synthetic Route by SureRoute
2. ACOPYO559 Molecular Building Block Synthetic Route
PROTAC TG2 degrader-1
(2S,4R)-1-((S)-3,3-Dimethyl-2-(5-(4-(5-((8-methyl-6-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-7-oxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-2-yl)amino)pyridin-2-yl)piperazin-1-yl)pentanamido)butanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
(2S,4R)-1-((S)-2-(2-(2-(2-(4-(5-((4-((3-Chloro-4-fluorophenyl)amino)-6-((E)-4-(piperidin-1-yl)but-2-enamido)quinazolin-7-yl)oxy)pentyl)-1H-1,2,3-triazol-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide