Account PROTAC SMARCA2 degrader-2
- Catalog No. :
- ACXIPB777
- CAS No. :
- 2892523-74-7
- Molecular Formula :
- C49H62N10O6S
- Molecular Weight :
- 919.17
IUPAC Name:(2S,4R)-4-hydroxy-1-((R)-2-(3-(2-(4-((3'-(2-hydroxyphenyl)-7',8'-dihydro-5'H-spiro[piperidine-4,6'-pyrazino[2,3-c]pyridazin]-1-yl)methyl)piperidin-1-yl)ethoxy)isoxazol-5-yl)-3-methylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
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5mg98%$482.00Login to see priceInquiryInquiry
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25mg98%$1426.00Login to see priceInquiryInquiry
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Product Information
| Product Name | PROTAC SMARCA2 degrader-2 |
|---|---|
| IUPAC Name | (2S,4R)-4-hydroxy-1-((R)-2-(3-(2-(4-((3'-(2-hydroxyphenyl)-7',8'-dihydro-5'H-spiro[piperidine-4,6'-pyrazino[2,3-c]pyridazin]-1-yl)methyl)piperidin-1-yl)ethoxy)isoxazol-5-yl)-3-methylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
| Molecular Formula | C49H62N10O6S |
| Molecular Weight | 919.17 |
| SMILES | O=C([C@H]1N(C([C@@H](C2=CC(OCCN3CCC(CN4CCC5(NC6=CC(C7=CC=CC=C7O)=NN=C6NC5)CC4)CC3)=NO2)C(C)C)=O)C[C@H](O)C1)N[C@H](C8=CC=C(C9=C(C)N=CS9)C=C8)C |
| InChI Key | BMFRLBNGYKVCHH-UOKCIILFSA-N |
| Synonym | PROTAC SMARCA2 degrader-2;(2S,4R)-4-hydroxy-1-[(2R)-2-{3-[2-(4-{[3'-(2-hydroxyphenyl)-7',8'-dihydro-5'H-spiro[piperidine-4,6'-pyridazino[3,4-b]pyrazin]-1-yl]methyl}piperidin-1-yl)ethoxy]-1,2-oxazol-5-yl}-3-methylbutanoyl]-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide;2-Pyrrolidinecarboxamide, 1-[(2R)-2-[3-[2-[4-[[7′,8′-dihydro-3′-(2-hydroxyphenyl)spiro[piperidine-4,6′(5′H)-pyrazino[2,3-c]pyridazin]-1-yl]methyl]-1-piperidinyl]ethoxy]-5-isoxazolyl]-3-methyl-1-oxobutyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (2S,4R)- |
| CAS No. | 2892523-74-7 |
Synthetic Route by SureRoute
2. ACXIPB777 Molecular Building Block Synthetic Route
PROTAC SMARCA2 degrader-1
(2S,4R)-4-Hydroxy-1-((R)-2-(3-(((S)-1-((R)-3-((S)-2-(2-hydroxyphenyl)-5,6,6a,7,9,10-hexahydro-8H-pyrazino[1',2':4,5]pyrazino[2,3-c]pyridazin-8-yl)pyrrolidin-1-yl)propan-2-yl)oxy)isoxazol-5-yl)-3-methylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
PROTAC BRM degrader-1