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Product Catalog
Chemicals
By Reaction Type
Product Catalog of By Reaction Type
123-Triazole
Huisgen Cycloaddition (1,4 regio)
Huisgen Cycloaddition (1,4 regio)(Click Reaction)
Huisgen Cycloaddition (1,5 regio)
124-Triazole
3,5-Disubstituted 1,2,4-Triazole formation from aryl nitriles and amidines
3,5-Disubstituted 1,2,4-Triazole formation from hydrazides
3,5-Disubstituted 1,2,4-Triazole formation from carboxylates
5-Het Amination
Amination of 5-member heterocycles (n-alkyl-imidazole, thiazole, oxazole, isoxazole, benzothiazole, benzimidazole, and benzoxazole)
5-Het Arylation
5-Member heterocycle arylation from aryl bromides
Acyl Sulfonamide Synthesis
Acyl sulfonamide synthesis from a sulfonamide and a carboxylic acid
Acyl sulfonamide synthesis from a sulfonamide and an acid chloride
Acylation
Ynone synthesis from alkynes and acid chlorides
Aldol Condensation
SpinPhox/Iridium-Catalyzed Asymmetric Hydrogenation of Cyclica-Alkylidene Carbonyl Compounds
Alkylation
Alkylation of amines using alkyl halides
N-Alkylation of heterocycles using alkyl halides
Amide Coupling
Amide synthesis from carboxylic acids and primary or secondary amines
Schotten-Baumann amide synthesis from acid chlorides and primary or secondary amines
Intramolecular amide coupling to form lactams
Intramolecular amide coupling to form quinolinones
Amination
Buchwald-Hartwig amination from aryl halides and primary or secondary amines
Reductive amination
Amino Thiophene Synthesis
Gewald amino thiophene synthesis
Barluenga-Valdes Coupling
Barluenga-Valdes Pd-catalyzed coupling between tosylhydrazones (from ketones) and aryl halides.
Barluenga-Valdes Pd-catalyzed coupling between tosylhydrazones (from aldehydes) and aryl halides.
Barluenga-Valdes reductive coupling between benzylic tosylhydrazones (from aldehydes/ketones) and boronates.
Metal-free coupling between saturated heterocyclic sulfonylhydrazones and boronates.
Barton-Zard Pyrrole Synthesis
Barton-Zard pyrrole synthesis
Aromatic Barton-Zard pyrrole synthesis
Benzimidazole Synthesis
2-Substituted benzimidazole formation from carboxylic acids or esters
2-Substituted benzimidazole formation from aldehydes
2-Chloro-benzimidazole formation
Benzimidazole formation
Benzofuran Synthesis
2-Substituted benzofuran synthesis from 2I-phenols and alkynes
Benzothiazole Synthesis
2-Substituted benzothiazole synthesis from 2SH-anilines and aldehydes
Benzothiophene Synthesis
Benzothiophene synthesis
Benzoxazole Synthesis
2-Substituted benzoxazole synthesis from 2NH-phenols and carboxylic acids or esters
2-Aryl benzoxazole synthesis from 2-aminophenols and aryl aldehydes
Boc Deprotection
Deprotection of a Boc-protected amine
Deprotection of a Boc-protected aromatic nitrogen
Boc Protection
Protection of a primary or secondary amine with a Boc-group
Protection of an aromatic nitrogen (nH) with a Boc-group
Buchwald-Hartwig Coupling
Buchwald-Hartwig: N-arylation of a primary or secondary sulfonamide using an aryl halide.
Carbamate Synthesis
Carbamate synthesis from isocyanates and primary or secondary alcohols
Carbamate synthesis from primary or secondary amines and primary or secondary alcohol
Castro-Stephens Coupling
Castro-Stephens coupling: synthesis of indoles
Castro-Stephens coupling: synthesis of disubstituted acetylenes
Chan-Lam Coupling
Chan-Lam coupling: N-arylation of anilines with boronic acids
Chan-Lam coupling: O-arylation of phenols with boronic acids
Chan-Lam coupling: S-arylation of thiophenols with boronic acids
Conrad-Limpach Reaction
Conrad-Limpach synthesis of substituted 4-hydroxyquinolines
Corey-Chaykovsky Reaction
Corey-Chaykovsky epoxidation
Corey-Chaykovsky cyclopropanation
Coumarin Synthesis
Pechmann coumarin synthesis
Crossed Claisen Reaction
Crossed Claisen reaction: 1,3-diketone synthesis from an enolizable ketone and a non-enolizable ester
Crossed Claisen condensation: beta-keto ester synthesis from an enolizable ester and a non-enolizable ester
Crossed Claisen reaction: 1,3-diketone synthesis from an enolizable ketone or aldehyde and an ester
Crossed Claisen reaction: beta-hydroxy ester synthesis from an enolizable ester and a ketone or aldehyde
Crossed Claisen reaction to form a beta-keto ester
Curtius Rearrangement
Curtius rearrangement of carboxylates to isocynates and addition of amines to form carbamates and carbonates
Curtius rearrangement of carboxylates to isocynates and addition of alcohols to form carbamates
Hydrolysis of isocyanates formed by Curtius rearrangement starting from carboxylates
Cyanohydrin Formation
Cyanohydrin formation from an aldehyde
Decarboxylative Coupling
Decarboxylative cross coupling reaction
Diels-Alder Reaction
Standard Diels-Alder reaction between a 1,4-unsubstituted diene and a dienophile
Standard Diels-Alder reaction between a 1-substituted diene and a dienophile
Standard Diels-Alder reaction between a 1,4-substituted diene and a dienophile
Diyne Synthesis
Heterocoupling of two alkynes to form a 1,3-diyne (implicit formation of a haloalkyne)
Epoxidation
Epoxidation of alkenes
Erlenmeyer-Plochl Reaction
Erlenmeyer-Plochl azlactone synthesis from aldehydes or ketones and N-acyl glycine
Ester Hydrolysis
Hydrolysis of an ester to the parent carboxylic acid.
Hydrolysis of an ester to the parent alcohol.
Esterification Reaction
Esterification reaction from alcohols and acid chlorides
Esterification reaction from alcohols and a carboxylic acid
Ether Synthesis
Ullmann aryl ether synthesis
Williamson ether synthesis
Palladium catalyzed aryl ether synthesis
Flavone Synthesis
Flavone synthesis from 2-acyl phenols and aryl acid chlorides.
Fmoc Deprotection
Deprotection of an Fmoc-protected amine
Fmoc Protection
Protection of a primary or secondary amine with an Fmoc-group
Friedel-Crafts Acylation
Friedel-Crafts acylation.
Friedlander Synthesis
Friedlander synthesis of a quinoline from an aldehyde or ketone and an ortho-aminocarbonyl compound.
Furan Synthesis
Feist-Benary furan synthesis from 1,3-diketones and 2-halo ketones.
Goldberg Reaction
Goldberg reaction of an aryl halide with an aniline or acetanilide.
Goldberg reaction of an aryl halide with a benzylpyrazolone.
Heck Reaction
Heck reaction
Hiyama Coupling
Hiyama coupling between aryl or vinyl halides and aryl organosilanes
Hiyama coupling between aryl or vinyl halides and vinyl organosilanes
Hiyama coupling between aryl halides and alkynyl organosilanes
Imidazole Synthesis
Synthesis of 2-substituted imidazoles
Synthesis of 1,2,4-substituted imidazoles
Synthesis of triaryl-imidazoles
Indole Synthesis
Bischler-Mohlau indole synthesis
Fischer indole synthesis
Isocyanate Formation
Isocyanate formation from primary amines.
Isoxazole Synthesis
Claisen isoxazole synthesis
Mitsunobu Reaction
Mitsunobu (alcohol)
Mitsunobu (sulfonamide)
Mitsunobu (2-substituted tetrazole)
Mitsunobu (1-substituted tetrazole)
Mitsunobu (ester)
Miyaura Borylation
Miyaura borylation
N-Azole Arylation
N-Arylation of azoles from boronic acids/esters
Negishi Coupling
Negishi Coupling
Oxadiazole Synthesis
Oxadiazole synthesis
Oxazole Synthesis
Fischer oxazole synthesis
2,4-Disubstituted oxazole synthesis
Phthalazinone Synthesis
Phthalazinone synthesis
Pictet-Spengler Cyclization
Pictet-Spengler cyclization
Pomeranz-Fritsch Reaction
Pomeranz-Fritsch synthesis of isoquinolines
Pyrazole Synthesis
Pyrazole synthesis from 1,3-diketones and hydrazine
Pyridine Synthesis
Hantzsch pyridine synthesis from two beta-ketoesters, an aldehyde, and ammonia (stepwise).
Krohnke pyridine synthesis from 2-halo ketone and an alfa,beta-unsaturated ketone
Guareshi-Thorpe pyridine synthesis
Pyridone Synthesis
Pyridone synthesis from cyanoacetamide and 1,3-diketones
Pyrimidine Synthesis
Pinner pyrimidine synthesis from a 1,3-diketones and an amidine
Pyrimidinedione Synthesis
Pyrimidinedione synthesis from amino-acrylates and isocyanates
Bicyclic pyrimidinedione synthesis from 2-aminobenzoates and isocyanates
Pyrimidone Synthesis
Biginelli synthesis of 2-pyrimidones from a beta-ketoester, an aldehyde and urea
Biginelli synthesis of 2-mercaptopyrimidines from a beta-ketoester, an aldehyde and thiourea
Pyrrole Synthesis
Knorr pyrrole synthesis from two beta-ketoesters
Paal-Knorr pyrrole synthesis
Quinazoline Synthesis
Quinazoline synthesis from a quinazolinone and a primary or secondary amine
Quinazolinone Synthesis
Quinazolinone Synthesis from a 2-carboxy aniline, a primary amine, and an aldehyde
Niementowski quinazolinone synthesis
Quinoline Synthesis
Quinoline synthesis
Niementowski quinoline synthesis
Rubottom Oxidation
Rubottom oxidation
Sonogashira Coupling
Sonogashira coupling
Spiro-Chromanone Synthesis
Spiro-chromanone Synthesis
Stille Coupling
Stille coupling
Stille carbonylative coupling
Substitution Reaction
substitution-SNAr
substitution with amine
substitution with phenol
substitution with alcohol and bromide
Sulfonamide Coupling
Sulfonamide coupling
Sulfone Synthesis
Oxidation of a thioether to a sulfone
Oxidation of a sulfoxide to a sulfone
Sulfoxide Synthesis
Oxidation of a thioether to a sulfoxide
Suzuki Coupling
Suzuki coupling of aryl/vinyl boronates with aryl/vinyl halides
Suzuki coupling of trifluoroborates and with aryl/vinyl halides
Tetrahydroindole Synthesis
Tetrahydroindole synthesis
Tetrazole Synthesis
2,5-disubstituted tetrazole synthesis
1,5-disubstituted tetrazole synthesis
Synthesis of a terminal tetrazole from a nitrile and sodium azide
Thiazole Synthesis
Hantzsch 2,5-disubstituted thiazole synthesis
Hantzsch 5-substituted thiazole synthesis
Thioether Synthesis
Thioether synthesis with styrene
Thioether synthesis with aryl or alkyl halides
Thiourea Synthesis
Thiourea synthesis from isocyanates
Urea Synthesis
Urea synthesis from isocyanates and primary or secondary amines
Urea synthesis from two primary or secondary amines
Urea synthesis from isocyanates and sulfonamide
Vilsmeier-Haack Formylation
Vilsmeier-Haack formylation of substituted phenyls (para)
Vilsmeier-Haack formylation of substituted phenols (ortho)
Vilsmeier-Haack formylation of 5-membered heterocycles
Vinyl Reduction
Reduction of arylvinyl groups
Yamaguchi Macrolactonization
Yamaguchi macrolactonization
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