Covalent Building Blocks (3608)

AiFChem’s Covalent Building Blocks primarily feature classic acrylamides and chloroacetamides. Rationally designed and synthesized specifically for protein target validation, they are ideal for hit identification and druggability assessment. Diverse synthetic handles facilitate the seamless "covalentization" of privileged scaffolds and non-covalent leads, enabling the rapid enumeration of high-quality covalent arrays via parallel synthesis. Furthermore, the synthetic feasibility of our novel covalent libraries has been well evaluated and confirmed, enabling their efficient and rapid synthesis and delivery to empower researchers in expanding druggable chemical space.