Account 3-(5-(4-((4-((1-(2-((4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-7-(8-ethynyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoropyrido[4,3-d]pyrimidin-2-yl)oxy)ethyl)piperidin-4-yl)methyl)piperidin-1-yl)methyl)piperidin-1-yl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
- Catalog No. :
- ACBKGC596
- CAS No. :
- 3052745-16-8
- Molecular Formula :
- C57H63F3N10O5
- Molecular Weight :
- 1025.19
IUPAC Name:3-(5-(4-((4-((1-(2-((4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-7-(8-ethynyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoropyrido[4,3-d]pyrimidin-2-yl)oxy)ethyl)piperidin-4-yl)methyl)piperidin-1-yl)methyl)piperidin-1-yl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
![3-(5-(4-((4-((1-(2-((4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-7-(8-ethynyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoropyrido[4,3-d]pyrimidin-2-yl)oxy)ethyl)piperidin-4-yl)methyl)piperidin-1-yl)methyl)piperidin-1-yl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione structure diagram](/images/productimg/no-pic.svg)
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Product Information
| Product Name | 3-(5-(4-((4-((1-(2-((4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-7-(8-ethynyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoropyrido[4,3-d]pyrimidin-2-yl)oxy)ethyl)piperidin-4-yl)methyl)piperidin-1-yl)methyl)piperidin-1-yl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
|---|---|
| IUPAC Name | 3-(5-(4-((4-((1-(2-((4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-7-(8-ethynyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoropyrido[4,3-d]pyrimidin-2-yl)oxy)ethyl)piperidin-4-yl)methyl)piperidin-1-yl)methyl)piperidin-1-yl)-4-fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
| Molecular Formula | C57H63F3N10O5 |
| Molecular Weight | 1025.19 |
| SMILES | C#CC1=C2C(C3=NC=C4C(N5CC6CCC(C5)N6)=NC(OCCN5CCC(CC6CCN(CC7CCN(C8=CC=C9C(=O)N(C%10CCC(=O)NC%10=O)CC9=C8F)CC7)CC6)CC5)=NC4=C3F)=CC(O)=CC2=CC=C1F |
| InChI Key | VUGUNNWXJMBUFV-UHFFFAOYSA-N |
| Synonym | 2,6-Piperidinedione, 3-[5-[4-[[4-[[1-[2-[[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-7-(8-ethynyl-7-fluoro-3-hydroxy-1-naphthalenyl)-8-fluoropyrido[4,3-d]pyrimidin-2-yl]oxy]ethyl]-4-piperidinyl]methyl]-1-piperidinyl]methyl]-1-piperidinyl]-4-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl]- |
| CAS No. | 3052745-16-8 |
Synthetic Route by SureRoute
2. ACBKGC596 Molecular Building Block Synthetic Route
(S)-3-(5-(2-((1-((1-(((7-(8-ethyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoro-4-((R)-3-hydroxy-3-methylpiperidin-1-yl)pyrido[4,3-d]pyrimidin-2-yl)oxy)methyl)cyclopropyl)methyl)-4-methylpiperidin-4-yl)methyl)-2,7-diazaspiro[3.5]nonan-7-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione
PROTAC KRAS G12C degrader-2
(2S,4R)-1-((2S)-2-(2-(4-((2S)-2-(((4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-7-(8-ethyl-7-fluoro-3-hydroxynaphthalen-1-yl)-8-fluoropyrido[4,3-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide