Enzyme Cleavable Linkers (Cleave Motif) (577)

Certain enzymes within intracellular lysosomes and the tumor microenvironment are capable of selectively cleaving linkers. For instance, lysosomal cathepsins can hydrolyze peptide bonds, including dipeptide or tetrapeptide linkers. Additionally, glycosidases can break down β-glucuronide and β-galactosidase, phosphatases can hydrolyze pyrophosphate bonds, and sulfatases can degrade sulfates.