Proteolysis Targeting Chimera Research Reagents (905)

PROTACs are composed of a small molecule ligand that attaches to a target protein and facilitates its interaction with an E3 ubiquitin ligase, leading to the protein's ubiquitination and subsequent degradation via the proteasome. These tools are utilized to investigate protein function, identify new drug targets, and develop innovative therapeutic approaches for conditions like cancer and neurodegenerative diseases.