Heterobifunctional PEG and Oligoethylene Glycols (21)

Heterobifunctional polyethylene glycol (PEG) contains distinct functional groups at each end of the PEG chain, enabling selective conjugation between two different molecules or surfaces. It is extensively utilized in bioconjugation reactions to link various molecules or surfaces, facilitating specific chemical and biological functions. Oligopolyethylene glycols (e.g., PEG-2, PEG-4) are primarily employed as solvents and penetration enhancers, aiding in the dissolution of active ingredients, improving stability and solubility, enhancing oral drug permeability and absorption, and ultimately increasing bioavailability.