Peptide Nucleic Acid (PNA) Monomers (130)

Peptide nucleic acid (PNA) is an innovative sequence-specific reagent for nucleic acids. Unlike conventional nucleic acids such as DNA and RNA, it features a polypeptide backbone in place of the traditional sugar-phosphate chain. Its key characteristics and functions include the following: 1. Distinct structure: PNA molecules consist of multiple amino acid residues linked by hydrogen bonds. Their structure differs from that of DNA and RNA, exhibiting a unique double-helix formation and spatial configuration. 2. High specificity in recognition: PNA molecules can bind to specific DNA or RNA sequences, forming stable complexes. Due to their distinct structure, PNAs demonstrate greater binding affinity to DNA and RNA compared to traditional nucleic acid probes. 3. Non-radioactive labeling: In contrast to traditional radioactive labeling techniques, PNAs can be labeled using non-radioactive methods, such as chemical synthesis, thereby eliminating the potential risks of radiation exposure to humans. 4. Excellent stability: PNA molecules are highly stable in aqueous solutions, resistant to photolysis and hydrolysis, and can be stored and utilized over extended periods.