Monofunctional PEG and Oligoethylene Glycols (84)

Monofunctional polyethylene glycol (PEG), characterized by a single reactive end, is widely utilized in PEGylation, surface grafting, and nanoparticle coating. It plays a significant role in bioconjugation, surface functionalization, and nanoparticle modification. In contrast, oligopolyethylene glycol (e.g., PEG-2, PEG-4) primarily serves as a solvent and penetration enhancer, aiding in the dissolution of active ingredients, improving stability and solubility, and enhancing the permeability and absorption of oral drugs, ultimately boosting bioavailability.