Peptide Nucleic Acid (PNA) Monomers (130)

Peptide nucleic acid (PNA) is an innovative sequence-specific reagent for nucleic acids. Unlike traditional nucleic acids such as DNA and RNA, it features a polypeptide backbone in place of the conventional sugar-phosphate chain. Its key characteristics and functions include the following: PNA possesses a distinct structure, as its molecules consist of multiple amino acid residues linked by hydrogen bonds. This structure differs from that of DNA and RNA, presenting a unique double helix and spatial configuration. PNA exhibits highly selective recognition, as it can bind to specific DNA or RNA sequences to form stable complexes. Its unique structure provides a stronger binding affinity to DNA and RNA compared to traditional nucleic acid probes. It allows for non-radioactive labeling, utilizing chemical synthesis methods rather than traditional radioactive labeling, thereby eliminating radiation-related risks to human health. Furthermore, PNA demonstrates excellent stability, remaining stable in aqueous solutions and resistant to photolysis and hydrolysis, enabling long-term storage and use.