CDK (484)

Cyclin-dependent kinase (CDK) is a critical regulator of the cell cycle, orchestrating progression through different phases by phosphorylating specific target proteins. Paired with cyclins, CDK facilitates essential processes like DNA replication and mitosis, ensuring accurate cell division. Dysregulated CDK activity, often caused by mutations in cyclins or other regulatory proteins, is a common feature of many cancers, driving uncontrolled cell proliferation. Consequently, CDK has emerged as a promising target for cancer therapy, with CDK inhibitors being developed to disrupt cell cycle progression and trigger cell death in cancer cells, thereby inhibiting tumor growth.