KRAS (2032)

KRAS is a pivotal oncogene implicated in numerous cancers, such as lung, colorectal, and pancreatic cancers. It produces a protein that regulates critical cell signaling pathways necessary for cell growth and survival. Mutations in KRAS result in its persistent activation, fueling tumor progression. Targeting KRAS has historically been challenging due to the absence of well-defined binding sites. Nevertheless, substantial advancements have been achieved in developing inhibitors that specifically target mutated KRAS proteins. Scientists are exploring small molecules and other cutting-edge strategies to inhibit KRAS activity, striving to address resistance mechanisms and introduce novel treatment options for cancer patients.

tert-butyl (R)-4-(hydroxymethyl)-2,2-dimethylpiperidine-1-carboxylate structure diagram

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KRAS (2032)

tert-butyl (R)-4-(hydroxymethyl)-2,2-dimethylpiperidine-1-carboxylate

2-(6-methoxynaphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-amino-4-bromo-1H-indole-3-carbonitrile

2-(8-chloro-3-(methoxymethoxy)naphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Ethyl (4-bromo-3-cyanobenzo[b]thiophen-2-yl)carbamate;Carbamic acid, N-(4-bromo-3-cyanobenzo[b]thien-2-yl)-, ethyl ester

tert-butyl 7-amino-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxylate

2-(7,8-difluoronaphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

tert-butyl 3,6-diazabicyclo[3.1.1]heptane-6-carboxylate

7-bromo-6,8-difluoroquinazoline-2,4(1H,3H)-dione

((2S,7aR)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol

7-bromo-2,4-dichloro-8-fluoroquinazoline

methyl 2-(bis(tert-butoxycarbonyl)amino)acrylate

(E)-4,4-difluorobut-2-enoic acid

3-bromo-5-chloro-4-(trifluoromethyl)aniline

2-(8-ethyl-3-(methoxymethoxy)naphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

tert-butyl 1-fluoro-3,8-diazabicyclo[3.2.1]octane-8-carboxylate

tert-butyl (4-bromo-7-fluorobenzo[b]thiophen-2-yl)carbamate

tert-butyl (3-cyano-7-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]thiophen-2-yl)carbamate

4-bromo-6-methyl-5-(trifluoromethyl)-1H-indazole

2,4,7-trichloro-8-fluoro-1,6-naphthyridine

1-bromo-3-chloro-2-iodo-5-nitrobenzene

tert-butyl (1S,2R,5R)-2-(hydroxymethyl)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate

2-(8-chloro-7-fluoronaphthalen-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

((2R,7aR)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol

4-(dimethylamino)-4-methylpent-2-ynoic acid hydrochloride

(3,3-difluoro-1-azabicyclo[3.2.0]heptan-5-yl)methanol

3-bromo-4-(difluoromethyl)pyridin-2-amine

2-(2-chloro-3-fluoropyridin-4-yl)acetonitrile

methyl (S)-3-amino-5-methylhexanoate hydrochloride

((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol