USP1 (187)

USP1 (Ubiquitin-Specific Protease 1) is a deubiquitinase enzyme essential for regulating protein stability and cellular functions by removing ubiquitin from specific target proteins. It plays a significant role in DNA damage repair, particularly by modulating the Fanconi anemia pathway, which is vital for preserving genomic stability. Elevated levels of USP1 have been associated with cancer progression, as it can promote DNA repair in tumor cells, leading to increased resistance to chemotherapy. As a result, targeting USP1 has emerged as a promising therapeutic approach to enhance cancer cell sensitivity to DNA-damaging agents and improve treatment efficacy.

2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-7-sulfonyl chloride structure diagram

Total: 20

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USP1 (187)

2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-7-sulfonyl chloride

4-fluoro-2-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2'-chlorospiro[cyclopropane-1,5'-pyrrolo[2,3-d]pyrimidin]-6'(7'H)-one

5-aminothiazolo[4,5-d]pyrimidin-2(3H)-one

tert-butyl 4-(hydroxymethyl)-3,3-dimethylpiperidine-1-carboxylate

5-chloro-1H-pyrazolo[4,3-d]pyrimidine

6-chloro-1H-pyrazolo[3,4-d]pyrimidine

(2-isopropylphenyl)boronic acid

5-chloro-3-methyl-1H-pyrazole

2-bromo-1-methyl-4-(trifluoromethyl)-1H-imidazole

4-chloro-6-cyclopropylpyrimidin-2-amine

(4-acetyl-2-fluorophenyl)boronic acid

ethyl 5-bromo-1-isopropyl-1H-pyrazole-4-carboxylate

1-isopropyl-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

(4-cyclopropyl-6-methoxypyrimidin-5-yl)boronic acid

(2-(2,2,2-trifluoroethoxy)pyridin-3-yl)boronic acid

2-chloro-4-iodopyrimidin-5-amine

(4-(1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl)phenyl)methanamine

(2-iodo-3-methylphenyl)(methyl)sulfane

(4-(1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl)phenyl)methanol