JAK (166)

JAK1, along with JAK2, JAK3, and TYK2, is part of the JAK (Janus-associated kinase) family of cytoplasmic tyrosine kinases, which are crucial for signal transduction mediated by cytokines and growth factors[1]. Aberrant JAK activity, resulting in constitutive activation of signal transducers and activators of transcription (STAT), is closely linked to immune-related diseases and cancers. Inhibiting JAK to disrupt the JAK/STAT signaling pathway has proven highly effective in treating these conditions.

benzyl (2S,5R)-5-amino-2-methylpiperidine-1-carboxylate structure diagram

Total: 27

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JAK (166)

benzyl (2S,5R)-5-amino-2-methylpiperidine-1-carboxylate

1-methyl-1H-indol-7-amine

benzyl ((1s,3s)-3-(methylamino)cyclobutyl)carbamate

tert-butyl (S)-2-(bromomethyl)pyrrolidine-1-carboxylate

benzyl (3R,4S)-3-(2-bromoacetyl)-4-ethylpyrrolidine-1-carboxylate

5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-amine

(1,1-dimethyl-1,3-dihydroisobenzofuran-5-yl)boronic acid

1-(difluoromethyl)-1H-pyrazole-4-carbaldehyde

tert-butyl ((1s,3s)-3-(methylamino)cyclobutyl)carbamate

4-chloro-7H-pyrrolo[2,3-d]pyrimidine

2-((2R,5S)-5-aminotetrahydro-2H-pyran-2-yl)acetonitrile hydrochloride

tert-butyl (2S,5R)-5-amino-2-methylpiperidine-1-carboxylate

(1S,2S)-cyclopentane-1,2-diamine dihydrochloride

5-ethyl-2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

ethyl 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-carboxylate

(1S,3R)-1,2,2-trimethylcyclopentane-1,3-dicarboxylic acid

N-(2-oxo-5-(trifluoromethyl)-1,2-dihydropyridin-3-yl)acetamide

(1R,2R,3R,5S)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-amine

4-Oxaspiro[2.4]heptan-7-one

3-(1-(tert-Butoxycarbonyl)pyrrolidin-3-yl)propiolic acid

(1R,2R)-cyclopentane-1,2-diamine dihydrochloride

1-(tetrahydro-2H-pyran-2-yl)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1H-pyrazole

3-bromo-1-methyl-1H-pyrazole-4-carbaldehyde

5-((tert-butoxycarbonyl)amino)pent-2-ynoic acid

3-bromo-4-chloro-5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

N-(4-hydroxypyridin-2-yl)acetamide

2-(1-(isopropylsulfonyl)azetidin-3-ylidene)acetonitrile