NLRP3 (372)

The NLRP3 inflammasome, a multimeric protein complex, consists of three structural domains: the leucine-rich repeat (LRR) domain, the nucleotide-binding and oligomerization (NACHT) domain, and the pyrin domain (PYD). As a distinctive pattern recognition receptor (PRR), NLRP3 can be broadly activated by bacterial, viral, and fungal pathogens, as well as environmental factors and host-derived signals. Dysregulated activation of the NLRP3 inflammasome has been linked to the development of numerous human diseases, contributing to both acute and chronic inflammation-associated conditions, such as arthritis, atherosclerosis, diabetes, multiple sclerosis, Alzheimer's disease, and Parkinson's disease. Consequently, targeting the NLRP3 inflammasome with specific inhibitors holds potential as a therapeutic strategy for these conditions.

1,4-dichloropyrido[3,4-d]pyridazine structure diagram

SY323724 | BS-44989 | EN300-6743086 | 1-(Iodomethyl)-2-oxabicyclo[2.1.1]hexane | D97008 | 1935986-52-9 | EN300-254077 | MFCD30486521 | (1s,4s)-1-(iodomethyl)-2-oxabicyclo[2.1.1]hexane

ACSNUL135

1935986-52-9

1-(2,2-difluorocyclopropyl)ethan-1-one structure diagram

Total: 27

Recently Added

NLRP3 (372)

1,4-dichloropyrido[3,4-d]pyridazine

3,3-dimethyl-2,3-dihydropyrazolo[5,1-b]oxazole-7-carboxylic acid

2-iodo-3-methyl-5-(trifluoromethyl)phenol

3-bromo-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine

1-isopropyl-1H-pyrazole-3-sulfonamide

3,6-dichloro-5-methyl-1,2,4-triazine

1,2,3,5,6,7-hexahydro-s-indacen-4-amine

4-cyclopropyl-2-methoxybenzoic acid

4-bromo-1,2,3,5,6,7-hexahydro-s-indacene

(3R,5R)-5-fluoro-1-methylpiperidin-3-amine dihydrochloride

2-methoxy-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

1,4-dichloro-5,6,7,8-tetrahydrophthalazine

(2-hydroxy-6-methyl-4-(trifluoromethyl)phenyl)boronic acid

1,4-dichlorophthalazine

5-bromo-2,3-dihydro-1H-inden-4-ol

SY323724 | BS-44989 | EN300-6743086 | 1-(Iodomethyl)-2-oxabicyclo[2.1.1]hexane | D97008 | 1935986-52-9 | EN300-254077 | MFCD30486521 | (1s,4s)-1-(iodomethyl)-2-oxabicyclo[2.1.1]hexane

1-(2,2-difluorocyclopropyl)ethan-1-one

6,7-Dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole-2-carboxylic acid

2-(4-chloro-2-fluoro-6-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(4-chloro-2-fluoro-6-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(3-chloro-2-fluoro-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

5-bromo-2,3-dihydro-1H-inden-4-amine

methyl 4-(cyanomethyl)-2-fluorobenzoate

3-(difluoromethylene)cyclobutan-1-amine hydrochloride

tert-butyl 1,4-dichloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyridazine-6-carboxylate

(1-(3-bromophenyl)-2,2-difluorocyclopropyl)methanamine

5-methyl-3-(methylsulfonyl)-1,2,4-triazine