GLP-1R (371)

Glucagon-like peptide-1 (GLP-1), secreted by intestinal L cells, enhances insulin secretion in a glucose-dependent manner by interacting with the GLP-1 receptor (GLP-1R). This receptor, part of the G-protein coupled receptor family, is predominantly expressed on pancreatic β cells and large ducts. Activation of GLP-1R has been shown to improve insulin secretion and support beta cell glucose sensing, transcription, synthesis, proliferation, and survival. GLP-1R agonists are currently under investigation for their potential roles in treating type 2 diabetes, obesity, and NASH.

tert-butyl (2,5-dioxopyrrolidin-3-yl)carbamate structure diagram

Total: 64

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GLP-1R (371)

tert-butyl (2,5-dioxopyrrolidin-3-yl)carbamate

(R)-4-methyl-1,3,2-dioxathiolane 2,2-dioxide

ethyl 5-bromo-1H-indole-2-carboxylate

tert-butyl (2S)-3-cyano-2-methyl-4-oxopiperidine-1-carboxylate

methyl 5-bromo-3-fluorothiophene-2-carboxylate

Ethyl 4-chloro-5-nitropicolinate

(R)-2-methoxypropan-1-amine

2-bromo-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one

3-Fluoro-2,2-dimethylpropan-1-ol

ethyl 5-bromo-2-iodothiazole-4-carboxylate

2-(4-chloro-2-fluorophenyl)ethan-1-ol

2-amino-3-bromo-6-fluorobenzoic acid

(4-fluoro-3,5-dimethylphenyl)hydrazine hydrochloride

2-(1-(aminomethyl)cyclopropyl)acetonitrile hydrochloride

1-(difluoromethyl)-5-iodo-1H-imidazole

4-(hydroxymethyl)-3-methoxybenzonitrile

tert-butyl (S)-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydropyridine-1(2H)-carboxylate

5-bromo-4-fluoro-1-methyl-1H-indazole

methyl 3,5-difluoro-4-nitrobenzoate

(R)-2-(bromomethyl)oxetane

tert-butyl 4-(6-chloropyridin-2-yl)piperidine-1-carboxylate

3,5-difluoro-4-nitrobenzoic acid

5-bromo-2-fluoro-1,3-dimethoxybenzene

4-iodo-2,2-dimethyltetrahydro-2H-pyran

5-bromo-4-fluoro-1H-indazole

methyl 3-fluoro-4-nitrobenzoate

Methyl 4-bromobenzo[b]thiophene-7-carboxylate

2-(benzyloxy)-6-bromopyridine

2-(3,6-dihydro-2H-pyran-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

3-fluoro-4-(hydroxymethyl)benzonitrile