Account PROTAC IRAK4 degrader-8
- Catalog No. :
- ACBEGY479
- CAS No. :
- 2911615-06-8
- Molecular Formula :
- C43H50ClF2N11O5
- Molecular Weight :
- 874.39
IUPAC Name:5-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(1-((1r,4R)-4-((9-(4-chloro-3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoyl)-3,9-diazaspiro[5.5]undecan-3-yl)methyl)cyclohexyl)-3-(difluoromethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
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Product Information
| Product Name | PROTAC IRAK4 degrader-8 |
|---|---|
| IUPAC Name | 5-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(1-((1r,4R)-4-((9-(4-chloro-3-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)benzoyl)-3,9-diazaspiro[5.5]undecan-3-yl)methyl)cyclohexyl)-3-(difluoromethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide |
| Molecular Formula | C43H50ClF2N11O5 |
| Molecular Weight | 874.39 |
| SMILES | O=C1CCN(C2=CC(C(=O)N3CCC4(CCN(C[C@H]5CC[C@H](N6C=C(NC(=O)C7=C8N=C(N9C[C@H]%10C[C@@H]9CO%10)C=CN8N=C7)C(C(F)F)=N6)CC5)CC4)CC3)=CC=C2Cl)C(=O)N1 |
| InChI Key | RGQCBKDSLKTVFN-PYYPWFDZSA-N |
| Synonym | PROTAC IRAK4 degrader-8;Pyrazolo[1,5-a]pyrimidine-3-carboxamide, N-[1-[trans-4-[[9-[4-chloro-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)benzoyl]-3,9-diazaspiro[5.5]undec-3-yl]methyl]cyclohexyl]-3-(difluoromethyl)-1H-pyrazol-4-yl]-5-(1R,4R)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl- |
| CAS No. | 2911615-06-8 |
Synthetic Route by SureRoute
2. ACBEGY479 Molecular Building Block Synthetic Route
5-((1R,4R)-2-Oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(difluoromethyl)-1-((1r,4R)-4-((4-((3-(1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-4-yl)prop-2-yn-1-yl)oxy)piperidin-1-yl)methyl)cyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
5-((1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl)-N-(3-(difluoromethyl)-1-((1r,4R)-4-formylcyclohexyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
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(R,Sp)-[2-(4'-i-Propyloxazolin-2'-yl)ferrocenyl]diphenylphosphine
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