Account PROTAC BRD4 Degrader-21
- Catalog No. :
- ACKGRF350
- CAS No. :
- 2503036-46-0
- Molecular Formula :
- C47H54Cl2N10O4S
- Molecular Weight :
- 925.99
IUPAC Name:(S)-4-(4-((4-((1-(2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)methyl)phenyl)-5-(2,4-dihydroxy-5-isopropylphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one hydrochloride
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Product Information
| Product Name | PROTAC BRD4 Degrader-21 |
|---|---|
| IUPAC Name | (S)-4-(4-((4-((1-(2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetyl)piperidin-4-yl)methyl)piperazin-1-yl)methyl)phenyl)-5-(2,4-dihydroxy-5-isopropylphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one hydrochloride |
| Molecular Formula | C47H54Cl2N10O4S |
| Molecular Weight | 925.99 |
| SMILES | O=C1NN=C(C2=CC(C(C)C)=C(O)C=C2O)N1C3=CC=C(CN4CCN(CC5CCN(C(C[C@H]6C7=NN=C(C)N7C8=C(C(C)=C(C)S8)C(C9=CC=C(Cl)C=C9)=N6)=O)CC5)CC4)C=C3.[H]Cl |
| InChI Key | BKCLODCLAKHBOU-KYYDUREMSA-N |
| Synonym | 3H-1,2,4-Triazol-3-one, 4-[4-[[4-[[1-[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetyl]-4-piperidinyl]methyl]-1-piperazinyl]methyl]phenyl]-5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-, hydrochloride (1:1);RNK-05047;3H-1,2,4-Triazol-3-one,4-[4-[[4-[[1-[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-Chemicalbookyl]acetyl]-4-piperidinyl]methyl]-1-piperazinyl]methyl] |
| CAS No. | 2503036-46-0 |
Synthetic Route by SureRoute
2. ACKGRF350 Molecular Building Block Synthetic Route
NICE-01
![2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)acetamide structure diagram](https://xchemchain-prod-1253699568.cos.ap-guangzhou.myqcloud.com/production/attachments/2026/07/22/drfq/1799711-21-9.png?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIDT0SoARehYSEnT2RxQiomY7TcckkZDlIx%2F20260801%2Fap-guangzhou%2Fs3%2Faws4_request&X-Amz-Date=20260801T220243Z&X-Amz-Expires=86400&X-Amz-SignedHeaders=host&response-content-disposition=attachment%3B%20filename%3D%221799711-21-9.png%22&x-id=GetObject&X-Amz-Signature=c9719b437b9822e679d2dc9f5ebb58aaae0baa491af4fc0459e03bee2e74145c)
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)acetamide
![2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)acetamide structure diagram](https://xchemchain-prod-1253699568.cos.ap-guangzhou.myqcloud.com/production/attachments/2026/07/22/icb6/1950634-92-0.png?X-Amz-Algorithm=AWS4-HMAC-SHA256&X-Amz-Credential=AKIDT0SoARehYSEnT2RxQiomY7TcckkZDlIx%2F20260801%2Fap-guangzhou%2Fs3%2Faws4_request&X-Amz-Date=20260801T220243Z&X-Amz-Expires=86400&X-Amz-SignedHeaders=host&response-content-disposition=attachment%3B%20filename%3D%221950634-92-0.png%22&x-id=GetObject&X-Amz-Signature=153415f7658bff614d3078c7641f4da3a0568e0953fddc59609fb19605835c21)
2-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-(8-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)octyl)acetamide