Account PROTAC SOS1 degrader-1
- Catalog No. :
- ACOGYN385
- CAS No. :
- 2913185-35-8
- Molecular Formula :
- C57H76ClFN10O4S
- Molecular Weight :
- 1051.82
IUPAC Name:(2S,4R)-1-((S)-2-(9-(4-(6-chloro-1-(4-fluoro-3,5-dimethylbenzyl)-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
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Product Information
| Product Name | PROTAC SOS1 degrader-1 |
|---|---|
| IUPAC Name | (2S,4R)-1-((S)-2-(9-(4-(6-chloro-1-(4-fluoro-3,5-dimethylbenzyl)-2-(2,6-diazaspiro[3.3]heptan-2-yl)-1H-benzo[d]imidazol-4-yl)piperazin-1-yl)nonanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide |
| Molecular Formula | C57H76ClFN10O4S |
| Molecular Weight | 1051.82 |
| SMILES | CC1=C(F)C(C)=CC(CN2C(N3CC4(CNC4)C3)=NC3=C(N4CCN(CCCCCCCCC(=O)N[C@H](C(=O)N5C[C@H](O)C[C@H]5C(=O)NC(C)C5=CC=C(C6=C(C)N=CS6)C=C5)C(C)(C)C)CC4)C=C(Cl)C=C32)=C1 |
| InChI Key | AZBRWXRYNYEDKG-HAGVEIHTSA-N |
| CAS No. | 2913185-35-8 |
Synthetic Route by SureRoute
2. ACOGYN385 Molecular Building Block Synthetic Route
PROTAC SOS1 degrader-2
(2S,4R)-1-((2S)-2-(4-(4-(((4-((1S,4S)-2,5-Diazabicyclo[2.2.1]heptan-2-yl)-6-cyclopropyl-7-(6-fluoro-5-methyl-1H-indazol-4-yl)-2-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-8-yl)oxy)methyl)phenyl)-1H-1,2,3-triazol-1-yl)-3-methylbutanoyl)-4-hydroxy-N-((R)-2-hydroxy-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
7-(3,5-Difluoropyridin-2-yl)-N-((S)-13-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-14,14-dimethyl-11-oxo-3,6,9-trioxa-12-azapentadecyl)-2-methyl-10-((methylsulfonyl)methyl)-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carboxamide
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