Account N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-((4-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)heptyl)piperazin-1-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide
- Catalog No. :
- ACVYUW335
- CAS No. :
- 2641601-67-2
- Molecular Formula :
- C54H67N7O8
- Molecular Weight :
- 942.17
IUPAC Name:N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-((4-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)heptyl)piperazin-1-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide
![N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-((4-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)heptyl)piperazin-1-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide structure diagram](/images/productimg/no-pic.svg)
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Product Information
| Product Name | N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-((4-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)heptyl)piperazin-1-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide |
|---|---|
| IUPAC Name | N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-((4-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)heptyl)piperazin-1-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide |
| Molecular Formula | C54H67N7O8 |
| Molecular Weight | 942.17 |
| SMILES | O=C(C1=CC(C2=CC=C(CN3CCN(CCCCCCCOC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)CC3)C=C2)=CC(N(CC)C7CCOCC7)=C1C)NCC8=C(C)C=C(C)NC8=O |
| InChI Key | LONVYJSHGSZBQY-UHFFFAOYSA-N |
| Synonym | PROTAC EZH2 Degrader-1;N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-4'-{[4-(7-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]oxy}heptyl)piperazin-1-yl]methyl}-5-[ethyl(oxan-4-yl)amino]-4-methyl-[1,1'-biphenyl]-3-carboxamide;N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-4'-((4-(7-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)heptyl)piperazin-1-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-[1,1'-biphenyl]-3-carboxamide;[1,1′-Biphenyl]-3-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-4′-[[4-[7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]heptyl]-1-piperazinyl]methyl]-5-[ethyl(tetrahydro-2H-pyran-4-yl)amino]-4-methyl- |
| CAS No. | 2641601-67-2 |
Safety Data
- Pictogram
- Signal Word
- Warning
- Hazard Statement(s)
- H302-H315-H319
- Precautionary Statement(s)
- P264-P270-P280-P301+P312+P330-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364-P501
Synthetic Route by SureRoute
2. ACVYUW335 Molecular Building Block Synthetic Route
YM281
(2S,4R)-1-((S)-2-(9-(4-((3'-(((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-5'-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4'-methyl-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)-9-oxononanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
(2S,4R)-1-((S)-2-(11-(3-(4-((3'-(((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-5'-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4'-methyl-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)propanamido)undecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide