Cross-Linkers (577)

Crosslinkers are primarily utilized to link antibodies with toxins. The linker connecting cytotoxic drugs to monoclonal antibodies serves as the central component of an ADC. A major challenge in developing effective ADCs lies in selecting an appropriate crosslinker. This crosslinker must ensure the active cytotoxic drug is released in or near the target cell. It plays a critical role in the successful delivery of cytotoxic drugs by ADCs and significantly influences the toxicity of ADC products. Premature drug release into the bloodstream can result in systemic toxicity and a reduced therapeutic index. The selection of a linker typically depends on factors such as the target, the drug, the internalization and degradation process of the antibody-antigen complex, and the specific properties of the drug being used.